Thursday, March 2nd - 4:00pm to 5:00pm

MIT Colloquium on the Brain and Cognition

Postsynaptic plasticity following temporally-controlled presynaptic neuron ablation in the adult retina

Felice Dunn, Ph.D.
Singleton Auditorium 46-3002
Public welcome

Remodeling of postsynaptic neurons in response to injury to their presynaptic partners occurs across neurodegenerative disorders. In the retina, limited understanding of the events following photoreceptor injury constitutes a major barrier in developing therapies to prevent or reverse vision loss. I will talk about the use a transgenic mouse that expresses diphtheria toxin receptor in a subset of cone photoreceptors, allowing for temporally controlled induction of cone ablation via diphtheria toxin injection. I will show results demonstrating that bipolar cell dendritic remodeling occurs within 7 days following loss of cones in the adult retina.

Mark Harnett