The Martinos Imaging Center at MIT hosts a suite of tools and facilities for studying brain activity in humans and animals.
The center has a 3T Siemens Magnetom Tim Trio 60 cm whole-body MRI with EPI, MR angiography, diffusion, perfusion, and spectroscopy capabilities for both neuro and body applications. The scanner is equipped with several interchangeable radiofrequency coils including some custom coils that are sized for children. The visual stimulus system for fMRI studies is projected through a wave guide and is displayed on a rear projection screen (Da-Lite). Eye movements can be monitored with an eyelink eyetracker. Audio stimuli are delivered via sensimetrics insert earphones. Behavioral responses can be monitored via a button response and trigger interface.
The center has a 9.4T Bruker Biospec 94_20 MRI scanner for high resolution scanning of small animals. The 20-cm bore is suitable for small animals including rodents, ferrets and squirrel monkeys. There is animal preparation room adjacent to scanner.
The center is equipped with a 128-channel Biosemi ActiveTwo electroencephalography (EEG) system. This system uses active electrode technology, which eliminates the need for scalp preparation during set-up while still providing excellent signal quality and improving the experience for research subjects. The EEG system is housed in a double-wall insulated, sound-attenuating, audiometric testing booth.
The MEG lab features an Elekta Triux scanner with 306 SQUID channels plus 128 channels for simultaneous EEG. The scanner is installed in a Vacuumschmelze 3-layer magnetically shielded room with active compensation coils. It is equipped with a high-fidelity projector and a 44" back-projection screen for visual stimuli, earphones for audio stimuli, a pair of electrical somatosensory stimulators, one-finger response pads, and a MEG-compatible eye tracking system.
A replica of the 3T MRI scanner is used to acclimatize subjects (especially children) to the scanning environment. The mock scanner includes an audiovisual system and touch-pad response device similar to those used in the real scanner. The mock scanner also simulates the noise and vibration of the real scanner. This allows subjects to become familiar with the procedures in a ‘kid-friendly’ environment prior to entering the real scanner, thereby allowing more efficient use of scan time and improving data quality.
Technical Documentation and Software
- This wiki page provides extensive technical documentation for investigators using the resources of the Martinos Imaging Center.
- Imaging software for artifact detection, connectivity analysis and ROI analysis has been developed by Sue Whitfield-Gabrieli and her colleagues, and is available here.