Huntington’s disease (HD) is an inherited neurodegenerative disorder that progressively affects movement and higher brain function. It is linked to mutations in the huntingtin gene. Our researchers study brain regions, such as the striatum, that are linked to movement. We also develop models that allow researchers to study genetic diseases like Huntington’s.
1 in 7,300
Individuals estimated to have HD in Western populations.SOURCE: Tabrizi et al.
Chromosomal "address" of huntingtin, the gene linked to HD, in the human genome.SOURCE: NCBI
Ann Graybiel studies the neural basis of learning and action strategies relevant to decision-making, making and breaking habits, affective state, and brain disorders.