Martha Constantine-Paton studied the formation and modification of synapses – the interconnections between neurons – in order to understand how experience shapes the wiring of the brain. By studying individual neurons in the visual system of developing animals, she showed that a class of molecules known as NMDA receptors plays an essential role in setting the strengths of synapses. NMDA receptors are thought to underlie many aspects of learning throughout life. Constantine-Paton also examined the role these receptors play in developmental disorders that have their origins in early life.
Constantine-Paton, a founding member of the McGovern Institute, is Emeritus Professor in the departments of Brain and Cognitive Sciences and Biology. She moved to MIT in 1999, having previously held professorships at Princeton University and later at Yale University where she was director of the Interdepartmental Neuroscience Program.
Honors and Awards
Member, American Academy of Arts and Sciences
Lifetime Achievement Award, Society for Neuroscience, 2012
Developmental loss of miniature N-methyl-D-aspartate receptor currents in NR2A knockout mice. Townsend, M., Yoshii, A., Mishina, M., Constantine-Paton, M. (2003).
Proc Natl Acad Sci USA 100, 1340-1345.
Bustos, FJ, Pandian, S, Haensgen, H, Zhao, JP, Strouf, H, Heidenreich, M et al.. Removal of a genomic duplication by double-nicking CRISPR restores synaptic transmission and behavior in the MyosinVA mutant mouse Flailer. bioRxiv. 2023; :. doi: 10.1101/2023.04.28.538685. PubMed PMID:37163068 PubMed Central PMC10168395.
Pandian, S, Zhao, JP, Murata, Y, Bustos, FJ, Tunca, C, Almeida, RD et al.. Myosin Va Brain-Specific Mutation Alters Mouse Behavior and Disrupts Hippocampal Synapses. eNeuro. 2020;7 (6):. doi: 10.1523/ENEURO.0284-20.2020. PubMed PMID:33229412 PubMed Central PMC7769881.
Bolton, AD, Constantine-Paton, M. Synaptic Effects of Dopamine Breakdown and Their Relation to Schizophrenia-Linked Working Memory Deficits. Front Synaptic Neurosci. 2018;10 :16. doi: 10.3389/fnsyn.2018.00016. PubMed PMID:29950984 PubMed Central PMC6008544.