Ian Wickersham develops genetic tools that provide more powerful and precise ways to study the organization of the brain. His lab invents techniques for targeting neurons based on their synaptic connectivity and gene expression patterns in order to cause them to express genes that allow the neurons to be studied and controlled by neuroscientists and clinicians. The goal of Wickersham’s work is to provide neuroscience with more effective ways of studying the brain, and potentially to provide clinical neurology with more effective ways of treating disorders of the brain.
One aspect of Wickersham’s work is to engineer systems to identify and manipulate neurons that are directly synaptically connected either to a targeted single neuron or to a genetically-defined neuronal population of interest. For his graduate thesis, Wickersham and colleagues pioneered the use of recombinant rabies virus as a “monosynaptic tracing” tool for neuroscience. A critical tool for connectomics, it identifies cells directly connected to a targeted neuronal group and allows them to be imaged or functionally manipulated based on their synaptic connectivity and gene expression patterns.
Ian Wickersham received his PhD in Neurosciences from the University of California, San Diego. He came to MIT in 2007 to work as a postdoc in the labs of Sebastian Seung then Ed Boyden. In 2013 Wickersham started the Genetic Neuroengineering Group at the McGovern Institute.
Adaikkan, C, Wang, J, Abdelaal, K, Middleton, SJ, Bozzelli, PL, Wickersham, IR et al.. Alterations in a cross-hemispheric circuit associates with novelty discrimination deficits in mouse models of neurodegeneration. Neuron. 2022;110 (19):3091-3105.e9. doi: 10.1016/j.neuron.2022.07.023. PubMed PMID:35987206 PubMed Central PMC9547933.
Takeuchi, D, Roy, D, Muralidhar, S, Kawai, T, Bari, A, Lovett, C et al.. Cingulate-motor circuits update rule representations for sequential choice decisions. Nat Commun. 2022;13 (1):4545. doi: 10.1038/s41467-022-32142-1. PubMed PMID:35927275 PubMed Central PMC9352796.
Zhang, Y, Roy, DS, Zhu, Y, Chen, Y, Aida, T, Hou, Y et al.. Targeting thalamic circuits rescues motor and mood deficits in PD mice. Nature. 2022;607 (7918):321-329. doi: 10.1038/s41586-022-04806-x. PubMed PMID:35676479 PubMed Central PMC9403858.