Listening to Synapses

Guoping Feng is interested in how synapses — the connections between neurons — contribute to neurodevelopmental and psychiatric diseases, including autism spectrum disorder (ASD) and schizophrenia. He leads research that uses molecular genetics combined with behavioral and electrophysiological methods to study the components of the synapse.

Feng is perhaps best known for pioneering a gene-based therapy that could reverse a severe form of autism that is caused by a single mutation in the SHANK3 gene. After genetically engineering the SHANK3 mutation in animal models using CRISPR-based technology, Feng’s gene-correction therapy greatly reduced SHANK3 symptoms, restoring the animals’ cognitive, behavioral, and motor functions.

Additionally, the lab has leveraged genetic technologies to help map the cellular diversity in the brain—a valuable tool in neuroscience research. Through understanding the molecular, cellular, and circuit changes underlying brain diseases and disorders, the Feng lab hopes to eventually inform new and more effective treatments for neurodevelopmental and psychiatric disorders.