How Biological Memory Really Works: Insights from the Man with the World’s Greatest Memory

 

Jim Karol exhibited no particular talent for memorizing anything early in his life. Far from being a savant, his grades in school were actually pretty bad and, after failing to graduate from college, he spent his 20’s working in a factory. He only started playing around with mnemonic techniques at the age of 49, merely as a means to amuse himself while he worked out on the treadmill. Then, in one of the most remarkable cognitive transformations in human history, he turned himself into the man with the world’s greatest memory. Whatever vast body of information is put before him — the US zip codes, the day of the week of every date in history, the first few thousand digits of pi, etc. — he voraciously commits to memory using his own inimitable mnemonic techniques. Moreover, unlike most other professional memorists, Jim has mastered the mental skill of permanently storing that information in long-term memory, as opposed to only short or medium-term memory. How does he do it?

To be sure, Jim has taken standard menmonic techniques to the next level. That said, it has been well-documented for over 2500 years that mnemonic techiques — such as the “Method of Loci” or the “Memory Palace” — dramatically enhance the memory capacity of anyone who uses them regularly. But is there any point to improving one’s memory in the age of the computer? Tony Dottino, the founder/executive director of the USA Memory Championship and a world reknown memory coach, will describe his experiences of teaching these techniques to all age groups.

Finally, does any of this have anything to do with the neuroscience of memory? McGovern Institute neuroscientist Robert Ajemian argues that it does and that one of the great intellectual misunderstandings in scientific history is that modern-day neuroscientists largely base their conceptualization of human memory on the computer metaphor. For this reason, neuroscientists usually talk of read/write operations, traces, engrams, storage/retrieval distinctions, etc. Ajemian argues that all of this is wrong for the brain, a highly distributed system which processes in parallel. The correct conceptualization of human memory is that of content-addressable memory implemented by attractor networks, and the success of mnemonic techniques, though largely ignored in current theories of memory, constitutes the ultimate proof. Ajemian will briefly outline these arguments.

Tan-Yang Center for Autism Research: Opening Remarks

June 12, 2017
Tan-Yang Center for Autism Research: Opening Remarks
Bob Desimone, Director of the McGovern Institute for Brain Research at MIT
Bob Millard, Chair of MIT Corporation
Lore Harp McGovern, Co-founder of the McGovern Institute for Brain Research at MIT
Hock E. Tan and K. Lisa Yang, Founders of the Tan-Yang Center for Autism Research

On June 12, 2017, the McGovern Institute hosted the launch celebration for the Hock E. Tan and K. Lisa Yang Center for Autism Research. The center is made possible by a kick-off commitment of $20 million, made by Lisa Yang and MIT alumnus Hock Tan ’75.

The Tan-Yang Center for Autism Research will support research on the genetic, biological and neural bases of autism spectrum disorders, a developmental disability estimated to affect 1 in 68 individuals in the United States. Tan and Yang hope their initial investment will stimulate additional support and help foster collaborative research efforts to erase the devastating effects of this disorder on individuals, their families and the broader autism community.

Feng Zhang Wins the 2017 Blavatnik National Award for Young Scientists

The Blavatnik Family Foundation and the New York Academy of Sciences today announced the 2017 Laureates of the Blavatnik National Awards for Young Scientists. Starting with a pool of 308 nominees – the most promising scientific researchers aged 42 years and younger nominated by America’s top academic and research institutions – a distinguished jury first narrowed their selections to 30 Finalists, and then to three outstanding Laureates, one each from the disciplines of Life Sciences, Chemistry and Physical Sciences & Engineering. Each Laureate will receive $250,000 – the largest unrestricted award of its kind for early career scientists and engineers. This year’s Blavatnik National Laureates are:

Feng Zhang, PhD, Core Member, Broad Institute of MIT and Harvard; Associate Professor of Brain and Cognitive Sciences and Biomedical Engineering, MIT; Robertson Investigator, New York Stem Cell Foundation; James and Patricia Poitras ’63 Professor in Neuroscience, McGovern Institute for Brain Research at MIT. Dr. Zhang is being recognized for his role in developing the CRISPR-Cas9 gene-editing system and demonstrating pioneering uses in mammalian cells, and for his development of revolutionary technologies in neuroscience.

Melanie S. Sanford, PhD, Moses Gomberg Distinguished University Professor and Arthur F. Thurnau Professor of Chemistry, University of Michigan. Dr. Sanford is being celebrated for developing simpler chemical approaches – with less environmental impact – to the synthesis of molecules that have applications ranging from carbon dioxide recycling to drug discovery.

Yi Cui, PhD, Professor of Materials Science and Engineering, Photon Science and Chemistry, Stanford University and SLAC National Accelerator Laboratory. Dr. Cui is being honored for his technological innovations in the use of nanomaterials for environmental protection and the development of sustainable energy sources.

“The work of these three brilliant Laureates demonstrates the exceptional science being performed at America’s premiere research institutions and the discoveries that will make the lives of future generations immeasurably better,” said Len Blavatnik, Founder and Chairman of Access Industries, head of the Blavatnik Family Foundation, and an Academy Board Governor.

“Each of our 2017 National Laureates is shifting paradigms in areas that profoundly affect the way we tackle the health of our population and our planet — improved ways to store energy, “greener” drug and fuel production, and novel tools to correct disease-causing genetic mutations,” said Ellis Rubinstein, President and CEO of the Academy and Chair of the Awards’ Scientific Advisory Council. “Recognition programs like the Blavatnik Awards provide incentives and resources for rising stars, and help them to continue their important work. We look forward to learning where their innovations and future discoveries will take us in the years ahead.”

The annual Blavatnik Awards, established in 2007 by the Blavatnik Family Foundation and administered by the New York Academy of Sciences, recognize exceptional young researchers who will drive the next generation of innovation by answering today’s most complex and intriguing scientific questions.

Tan-Yang Center for Autism Research: Feng Zhang

June 12, 2017
Tan-Yang Center for Autism Research: Launch Celebration
Feng Zhang, McGovern Institute for Brain Research
“Gene Therapy for the Brain”

McGovern Institute 2017 Retreat

On June 5-6, McGovern researchers and staff gathered in Newport, Rhode Island for the annual McGovern Institute retreat. The overnight retreat featured talks, a poster session, a Newport Harbor cruise (for those willing to brave the cool, wet weather) and a dance party. Click the thumbnails below to see other images from the McGovern Institute Retreat.

2017 Sharp Lecture: Larry Abbott

March 20, 2017
Phillip A. Sharp Lecture in Neural Circuits
Sponsored by Biogen Idec

“Unmarring the Perceptron: Lessons in Cerebellar Computing from Fish and Flies”
Larry Abbott, Columbia University