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Silent synapses are abundant in the adult brain

MIT neuroscientists have discovered that the adult brain contains millions of “silent synapses” — immature connections between neurons that remain inactive until they’re recruited to help form new memories. Until now, it was believed that silent synapses were present only during early development, when they help the brain learn the new information that it’s exposed […]


New CRISPR-based tool inserts large DNA sequences at desired sites in cells

Building on the CRISPR gene-editing system, MIT researchers have designed a new tool that can snip out faulty genes and replace them with new ones, in a safer and more efficient way. Using this system, the researchers showed that they could deliver genes as long as 36,000 DNA base pairs to several types of human […]


Virtual Tour

Explore our labs, learn about our tools and technologies, and meet some of our brain researchers — all with the click of a mouse. With technical support and guidance from the MIT.nano Immersion Lab, our team took more than 500 panoramic photographs of the McGovern Institute and stitched them together to create this immersive experience, […]


Ila Fiete wins Swartz Prize for Theoretical and Computational Neuroscience

The Society for Neuroscience (SfN) has awarded the Swartz Prize for Theoretical and Computational Neuroscience to Ila Fiete, professor in the Department of Brain and Cognitive Sciences, associate member of the McGovern Institute for Brain Research, and director of the K. Lisa Yang Integrative Computational Neuroscience Center. The SfN, the world’s largest neuroscience organization, announced […]


How touch dampens the brain’s response to painful stimuli

When we press our temples to soothe an aching head or rub an elbow after an unexpected blow, it often brings some relief. It is believed that pain-responsive cells in the brain quiet down when these neurons also receive touch inputs, say scientists at MIT’s McGovern Institute, who for the first time have watched this […]


Not every reader’s struggle is the same

Many children struggle to learn to read, and studies have shown that students from a lower socioeconomic status (SES) background are more likely to have difficulty than those from a higher SES background. MIT neuroscientists have now discovered that the types of difficulties that lower-SES students have with reading, and the underlying brain signatures, are, […]


RNA-activated protein cutter protects bacteria from infection

Our growing understanding of the ways bacteria defend themselves against viruses continues to change the way scientists work and offer new opportunities to improve human health. Ancient immune systems known as CRISPR systems have already been widely adopted as powerful genome editing tools, and the CRISPR toolkit is continuing to expand. Now, scientists at MIT’s […]


Study urges caution when comparing neural networks to the brain

Neural networks, a type of computing system loosely modeled on the organization of the human brain, form the basis of many artificial intelligence systems for applications such speech recognition, computer vision, and medical image analysis. In the field of neuroscience, researchers often use neural networks to try to model the same kind of tasks that […]


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