By activating a brain circuit that controls compulsive behavior, researchers in Ann Graybiel‘s lab have shown that they can block a compulsive behavior in mice — a result that could help researchers develop new treatments for diseases such as obsessive-compulsive disorder (OCD) and Tourette’s syndrome. Read the story >>
Author: Julie Pryor
Neville Hogan: 2013 McGovern Institute Symposium
The annual McGovern Institute symposium took place on May 8, 2013 and featured nine talks on the subject of motor control and the motor cortex. In this video, Neville Hogan of MIT presents his talk entitled, “Modular dynamics in motor control and neuro-rehabilitation.”
Emile Bruneau: Tweaking the Empathy Gap
Emile Bruneau, a postdoctoral associate in Rebecca Saxe’s lab at the McGovern Institute, is interested in the psychology of human conflict. He is working with Saxe to figure out why empathy — the ability to feel compassion for another person’s suffering — often fails between members of opposing conflict groups. Bruneau is also trying to locate patterns of brain activity that correlate with empathy, in hopes of eventually using such measures to determine how well people respond to reconciliation programs aimed at boosting empathy between groups in conflict.
Read more about Emile Bruneau’s work in the New York Times magazine.
Ann Graybiel Meets the President of the United States
President Barack Obama greets the 2012 U.S. Kavli Prize Laureates in the Oval Office, March 28, 2013.
MIT researchers join Obama for brain announcement
Four MIT neuroscientists were among those invited to the White House on Tuesday, April 2, when President Barack Obama announced a new initiative to understand the human brain.
Professors Ed Boyden, Emery Brown, Robert Desimone and Sebastian Seung were among a group of leading researchers who joined Obama for the announcement, along with Francis Collins, director of the National Institutes of Health, and representatives of federal and private funders of neuroscience research.
In unveiling the BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative, Obama highlighted brain research as one of his administration’s “grand challenges” — ambitious yet achievable goals that demand new innovations and breakthroughs in science and technology.
A key goal of the BRAIN Initiative will be to accelerate the development of new technologies to visualize brain activity and to understand how this activity is linked to behavior and to brain disorders.
“There is this enormous mystery waiting to be unlocked,” Obama said, “and the BRAIN Initiative will change that by giving scientists the tools they need to get a dynamic picture of the brain in action and better understand how we think and how we learn and how we remember. And that knowledge could be — will be — transformative.”
To jump-start the initiative, the NIH, the Defense Advanced Research Projects Agency, and the National Science Foundation will invest some $100 million in research support beginning in the next fiscal year. Planning will be overseen by a working group co-chaired by Cornelia Bargmann PhD ’87, now at Rockefeller University, and William Newsome of Stanford University. Brown, an MIT professor of computational neuroscience and of health sciences and technology, will serve as a member of the working group.
Boyden, the Benesse Career Development Associate Professor of Research in Engineering, has pioneered the development of new technologies for studying brain activity. Desimone, the Doris and Don Berkey Professor of Neuroscience, is director of MIT’s McGovern Institute for Brain Research, which conducts research in many areas relevant to the new initiative. Seung, a professor of computational neuroscience and physics, is a leader in the field of “connectomics,” the effort to describe the wiring diagram of the brain.
2013 Scolnick Prize Lecture: Thomas Jessell
Dr. Thomas Jessell of Columbia University is the winner of the 2013 Scolnick Prize in Neuroscience for his pioneering work on synaptic plasticity, the process by which the brain’s connections are modified in response to experience.
On April 1, 2013, he delivered the Scolnick Prize lecture, entitled “Sifting Circuits for Motor Control.”
Brain Scan Cover Image: Winter 2013
The cover of the Winter 2013 issue of Brain Scan features an artist’s representation of a new genome editing technique developed by Feng Zhang. The method allows researchers to disrupt or replace genes at will.
2013 Sharp Lecture in Neural Circuits: Karel Svoboda
On March 14, 2013, Dr. Karel Svoboda of HHMI delivered the second annual Sharp Lecture in Neuroscience. Dr. Svoboda’s lab is working on the structure, function and plasticity of neocortical circuits.
Martha Constantine-Paton to receive top honors from Tufts University
Martha Constantine-Paton will receive the Dean’s Medal from Tufts University’s School of Arts and Sciences for her “exceptional contributions to the field of developmental neuroscience.” Constantine-Paton, a Tufts alumna, refers to her time at the university as a “turning point” in her life and credits the school for giving her the self-confidence she needed to pursue a career in science. The Dean’s Medal is the highest honor available at each school at Tufts, reserved only “for those select individuals who have made outstanding contributions to the university and to the greater community.”
Constantine-Paton will be awarded the Dean’s Medal on March 25, 2013.
Ed Boyden to share prestigious brain prize
Ed Boyden, a faculty member in the MIT Media Lab and the McGovern Institute for Brain Research, was today named a recipient of the 2013 Grete Lundbeck European Brain Research Prize. The 1 million Euro prize is awarded for the development of optogenetics, a technology that makes it possible to control brain activity using light.
The Brain Prize is awarded annually by the Denmark-based Lundbeck Foundation for outstanding contributions to European neuroscience. Boyden is recognized for work done in collaboration with Karl Deisseroth at Stanford University, which builds on earlier discoveries by four European researchers: Ernst Bamberg, Georg Nagel and Peter Hegemann in Germany, and Gero Miesenböck, now in Oxford, U.K. The prize will be shared equally between all six researchers.
The idea of using light to control brain activity was suggested by Francis Crick in 1999, and Miesenbock performed a proof of concept demonstration in 2002, showing that light-sensitive proteins obtained from the eyes of fruit-flies could be used to activate mammalian neurons. A further breakthrough was enabled by the discovery of channelrhodopsin-2 (ChR2), a light-activated ion channel from a common pond algal species that had been characterized by Hegemann in Martinsried and by Nagel and Bamberg in Frankfurt.
The application of ChR2 to neuroscience was pioneered by Boyden and Deisseroth at Stanford University, where Deisseroth is now a faculty member. In a collaboration that began when Boyden was a graduate student and Deisseroth a postdoctoral fellow, they obtained the ChR2 gene from Nagel and Bamberg, expressed it in cultured neurons, and pulsed the dish with blue light to see whether it could trigger neural activity. The first experiment was performed in August 2004, and it worked first time; as Boyden recounted in a recent historical article, “serendipity had struck — the molecule was good enough in its wild-type form to be used in neurons right away.”
They reported this result in 2005, in a landmark paper in Nature Neuroscience that has now been cited more than 600 times. Their method, later dubbed “optogenetics,” is now used by hundreds of labs worldwide and is also being explored for a wide range of potential therapeutic applications. In announcing the Brain Prize, the chairman of the selection committee, Professor Colin Blakemore, described optogenetics as “arguably the most important technical advance in neuroscience in the past 40 years.”
Boyden joined the MIT faculty in 2006, where he is now the Benesse Career Development Professor in the Media Lab, with joint appointments at the McGovern Institute for Brain Research and in the Departments of Biological Engineering and Brain and Cognitive Sciences. His contributions have been recognized by numerous awards and honors, including the inaugural AF Harvey Prize and the 2011 Perl/UNC prize (shared with Karl Deisseroth and with Feng Zhang, also at MIT). He continues to develop novel optogenetic tools, along with many other technologies for understanding and manipulating neural circuits within the living brain.
Boyden’s work was supported by the Fannie and John Hertz Foundation, the Helen Hay Whitney Foundation, the McKnight Foundation, Jerry and Marge Burnett, DARPA and the Department of Defense, Google, Harvard/MIT Joint Grants Program in Basic Neuroscience, Human Frontiers Science Program, IET A. F. Harvey Prize, MIT McGovern Institute and MIT Media Lab, NARSAD, New York Stem Cell Foundation-Robertson Investigator Award, NIH, NSF, Paul Allen Distinguished Investigator in Neuroscience Award, Shelly Razin, SkTech, Alfred P. Sloan Foundation, the Society for Neuroscience Research Award for Innovation in Neuroscience (RAIN), and the Wallace H. Coulter Foundation.